Centre for Integrative Biological Signalling Studies
Cluster of Excellence, University of Freiburg

Prof. Dr. Gerald Radziwill

Prof. Dr. Gerald Radziwill

Institute of Biology II - Biochemistry (Faculty of Biology)
University of Freiburg

+49 761 203 2635

CIBSS Research Project:

  • Control metabolic pathways by optogenetically-regulated AMPK and AKT


10 selected publications

  • OpEn-Tag-A Customizable Optogenetic Toolbox To Dissect Subcellular Signaling.
    Mühlhäuser WWD, Weber W, Radziwill G. (2019)
    ACS Synth Biol 19, 1679-1684
  • Optogenetic control of focal adhesion kinase signaling.
    Hörner M, Chatelle C, Mühlhäuser WWD, Stocker DR, Coats M, Weber W, Radziwill G. (2018).
    Cellular Signalling 42, 176–183.
  • Membrane localization of acetylated CNK1 mediates a positive feedback on RAF/ERK signaling.
    Fischer A, Mühlhäuser WWD, Warscheid B, Radziwill G (2017).
    Science Advances 3: e1700475
  • AKT-dependent phosphorylation of the SAM domain induces oligomerization and activation of the scaffold protein CNK1.
    Fischer A, Weber W, Warscheid B, Radziwill G (2017).
    Biochim Biophys Acta - Mol Cell Res 1864, 89-100.
  • Optogenetic clustering of CNK1 reveals mechanistic insights in RAF and AKT signaling controlling cell fate decisions.
    Fischer A, Warscheid B, Weber W, Radziwill G (2016)
    Scientific Reports 6:38155.
  • Optogenetically controlled RAF to characterize BRAF and CRAF protein kinase inhibitors.
    Chatelle CV, Hövermann D, Müller A, Wagner HJ, Weber W, Radziwill G. (2016)
    Scientific Reports 6:23713. doi:10.1038/srep23713.
  • Differential tyrosine phosphorylation controls the function of CNK1 as a molecular switch in signal transduction.
    Fischer A, Brummer T, Warscheid B, Radziwill G. (2015)
    Biochim Biophys Acta - Mol Cell Res 1853, 2847-2855.
  • Optogenetic control of protein kinase activity in mammalian cells.
    Wend,S, Wagner HJ, MüllerK, Zurbriggen MD, Weber W, Radziwill G. (2014).
    ACS Synth Biol 3, 280-285.
  • CNK1 is a novel Akt interaction partner that promotes cell proliferation through the Akt/FoxO signalling axis.
    Fritz RD, Varga Z, Radziwill G. (2010).
    Oncogene 29, 3575-3582.
  • CNK1 promotes invasion of cancer cells through NF-kappaB-dependent signalling.
    Fritz RD, Radziwill G. (2010).
    Mol Cancer Res 8, 395-406.