Centre for Integrative Biological Signalling Studies
Cluster of Excellence, University of Freiburg

Prof. Dr. Nils Wiedemann

Prof. Dr. Nils Wiedemann

Institute for Biochemistry and Molecular Biology (Faculty of Medicine),
University of Freiburg

+49 761 203 5280

CIBSS Research Project:

 

10 selected publications:

  • Structure of the mitochondrial import gate reveals distinct preprotein paths.
    Araiso Y, Tsutsumi A, Qiu J, Imai K, Shiota T, Song J, Lindau C, Wenz LS, Sakaue H, Yunoki K, Kawano S, Suzuki J, Wischnewski M, Schütze C, Ariyama H, Ando T, Becker T, Lithgow T, Wiedemann N, Pfanner N, Kikkawa M, Endo T (2019).
    Nature. 575(7782):395-401
  • Structural basis of membrane protein chaperoning through the mitochondrial intermembrane space.
    Weinhäupl K, Lindau C, Hessel A, Wang Y, Schütze C, Jores T, Melchionda L, Schönfisch B, Kalbacher H, Bersch B, Rapaport D, Brennich M, Lindorff-Larsen K, Wiedemann N, Schanda P (2018).
    Cell. 175(5):1365-1379.e25
  • Membrane protein insertion through a mitochondrial β-barrel gate.
    Höhr AIC, Lindau C, Wirth C, Qiu J, Stroud DA, Kutik S, Guiard B, Hunte C, Becker T, Pfanner N, Wiedemann N (2018).
    Science 359, eaah6834.
  • Definition of a High-Confidence Mitochondrial Proteome at Quantitative Scale.
    Morgenstern M, Stiller SB, Lübbert P, Peikert CD, Dannenmeier S, Drepper F, Weill U, Höß P, Feuerstein R, Gebert M, Bohnert M, van der Laan M, Schuldiner M, Schütze C, Oeljeklaus S, Pfanner N, Wiedemann N*, Warscheid B* (2017).
    Cell Rep. 19, 2836–2852. (* corresponding)
  • Mitochondrial OXA translocase plays a major role in biogenesis of inner-membrane proteins.
    Stiller SB, Höpker J, Oeljeklaus S, Schütze C, Schrempp SG, Vent-Schmidt J, Horvath SE, Frazier AE, Gebert N, van der Laan M, Bohnert M, Warscheid B, Pfanner N, Wiedemann N (2016).
    Cell Metabolism 23, 901–908.
  • Sam37 is crucial for formation of the mitochondrial TOM-SAM supercomplex, thereby promoting β-barrel biogenesis.
    Wenz L-S, Ellenrieder L, Qiu J, Bohnert M, Zufall N, van der Laan M, Pfanner N*, Wiedemann N*, Becker T (2015).
    J Cell Biol 210, 1047–1054. (* corresponding)
  • Coupling of Mitochondrial Import and Export Translocases by Receptor-Mediated Supercomplex Formation.
    Qiu J, Wenz L-S, Zerbes RM, Oeljeklaus S, Bohnert M, Stroud DA, Wirth C, Ellenrieder L, Thornton N, Kutik S, Wiese S, Schulze-Specking A, Zufall N, Chacinska A, Guiard B, Hunte C, Warscheid B, van der Laan M, Pfanner N*, Wiedemann N*, Becker T (2013).
    Cell 154, 596–608. (* corresponding)
  • Dual Function of Sdh3 in the Respiratory Chain and TIM22 Protein Translocase of the Mitochondrial Inner Membrane.
    Gebert N, Gebert M, Oeljeklaus S, Malsburg von der K, Stroud DA, Kulawiak B, Wirth C, Zahedi RP, Dolezal P, Wiese S, Simon O, Schulze-Specking A, Truscott KN, Sickmann A, Rehling P, Guiard B, Hunte C, Warscheid B, van der Laan M, Pfanner N, Wiedemann N (2011).
    Mol Cell 44, 811–818.
  • Dissecting membrane insertion of mitochondrial β-barrel proteins.
    Kutik S, Stojanovski D, Becker L, Becker T, Meinecke M, Krüger V, Prinz C, Meisinger C, Guiard B, Wagner R, Pfanner N and Wiedemann N (2008).
    Cell 132, 1011-1024.
  • Machinery for protein sorting and assembly in the mitochondrial outer membrane.
    Wiedemann N, Kozjak V, Chacinska A, Schönfisch B, Rospert S, Ryan MT, Pfanner N and Meisinger C (2003).
    Nature 424, 565-571.