Centre for Integrative Biological Signalling Studies
Cluster of Excellence, University of Freiburg

Prof. Dr. Sebastian Arnold

Prof. Dr. Sebastian Arnold

Institute of Experimental and Clinical Pharmacology and Toxicology (Faculty of Medicine)
University of Freiburg

+47 761 203 96819

CIBSS Research Project:


10 selected publications

  • Direct reprogramming of fibroblasts into renal tubular epithelial cells by defined transcription factors.
    Kaminski MM, Tosic J, Kresbach C, Engel H, Klockenbusch J, Müller AL, Pichler R, Grahammer F, Kretz O, Huber TB, Walz G, Arnold SJ, Lienkamp SS (2016).
    Nat Cell Biol. 18(12):1269-1280
  • Cyclin O (Ccno) functions during deuterosome-mediated centriole amplification of multiciliated cells.
    Funk MC, Bera AN, Menchen T, Kuales G, Thriene K, Lienkamp SS, Dengjel J, Omran H, Frank M, Arnold SJ (2015).
    EMBO J. 2015;34(8):1078-89.
  • Lysine-specific demethylase 1 regulates differentiation onset and migration of trophoblast stem cells.
    Zhu D, Hölz S, Metzger E, Pavlovic M, Jandausch A, Jilg C, Galgoczy P, Herz C, Moser M, Metzger D, Günther T*, Arnold SJ*, Schüle R* (2014).
    Nat Commun. 5:3174. * corresponding authors
  • Differentiation of type 1 ILCs from a common progenitor to all helper-like innate lymphoid cell lineages.
    Klose CSN, Flach M, Möhle L, Rogell L, Hoyler T, Ebert K, Fabiunke C, Pfeifer D, Sexl V, Fonseca-Pereira D, Domingues RG, Veiga-Fernandes H, Arnold SJ, Busslinger M, Dunay IR, Tanriver Y, Diefenbach A (2014).
    Cell. 157(2):340-356
  • The T-box transcription factor Eomesodermin acts upstream of Mesp1 to specify cardiac mesoderm during mouse gastrulation.
    Costello I, Pimeisl IM, Dräger S, Bikoff EK, Robertson EJ, Arnold SJ (2011).
    Nat Cell Biol. 13(9):1084-91
  • Pluripotency factors regulate definitive endoderm specification through eomesodermin.
    Teo AK, Arnold SJ, Trotter MW, Brown S, Ang LT, Chng Z, Robertson EJ, Dunn NR, Vallier L (2011).
    Genes Dev. 25(3):238-50.
  • Making a commitment: cell lineage allocation and axis patterning in the early mouse embryo.
    Arnold SJ, Robertson EJ (2009).
    Nat Rev Mol Cell Biol. 10(2):91-103
  • Pivotal roles for eomesodermin during axis formation, epithelium-to-mesenchyme transition and endoderm specification in the mouse.
    Arnold SJ, Hofmann UK, Bikoff EK, Robertson EJ (2008).
    Development. 135(3):501-11.
  • The T-box transcription factor Eomes/Tbr2 regulates neurogenesis in the cortical subventricular zone.
    Arnold SJ, Huang GJ, Cheung AF, Era T, Nishikawa S, Bikoff EK, Molnár Z, Robertson EJ, Groszer M (2008).
    Genes Dev. 22(18):2479-84
  • Brachyury is a target gene of the Wnt/beta-catenin signaling pathway.
    Arnold SJ, Stappert J, Bauer A, Kispert A, Herrmann BG, Kemler R (2000).
    Mech Dev. 91(1-2):249-58.