Centre for Integrative Biological Signalling Studies
Cluster of Excellence, University of Freiburg

Dr. Erika Pearce

Dr. Erika Pearce

Max-Planck-Institute of Immunobiology and Epigenetics Freiburg

+49 761 5108 450

CIBSS Research Project:

 

10 selected publications:

  • Polyamines and eIF5A hypusination modulate mitochondrial respiration and macrophage activation.
    Puleston DJ, Buck MD, Klein Geltink RI, Kyle RL, Caputa G, O'Sullivan D, Cameron AM, Castoldi A, Musa Y, Kabat AM, Zhang Y, Flachsmann LJ, Field CS, Patterson AE, Scherer S, Alfei F, Baixauli F, Austin SK, Kelly B, Matsushita M, Curtis JD, Grzes KM, Villa M, Corrado M, Sanin DE, Qiu J, Pällman N, Paz K, Maccari ME, Blazar BR, Mittler G, Buescher JM, Zehn D, Rospert S, Pearce EJ, Balabanov S, Pearce EL (2019).
    Cell Metab. 30 pii: S1550-4131(19)30243-8
  • Mitochondrial priming by CD28.
    Klein Geltink RI, O’Sullivan D, Corrado M, Bremser A, Buck MD, Buescher JM, Firat E, Zhu X, Niedermann G, Caputa G, Kelly B, Warthorst U, Rensing-Ehl A, Kyle RL, Vandersarren L, Curtis JD, Patterson AE, Lawless S, Grzes K, Qiu J, Sanin DE, Kretz O, Huber TB, Janssens S, Lambrecht BN, Rambold AS, Pearce EJ, Pearce EL (2017).
    Cell 171, 385-397
  • Mitochondrial dynamics controls T cell fate through metabolic reprogramming.
    Buck MD, O’Sullivan D, Klein Geltink RI, Curtis JD, Chang CH, Sanin DE, Qiu J, Kretz O, Braas D, van der Windt GJW, Chen Q, Huang S, O’Neill CM, Edelson BT, Pearce EJ, Sesaki H, Huber TB, Rambold AS, Pearce EL (2016).
    Cell 166, 63-76.
  • Metabolic competition in the tumor microenvironment is a driver of cancer progression.
    Chang CH*, Qiu J*, O’Sullivan D, Buck MD, Noguchi T, Curtis JD, Chen Q, Gindin M, Gubin MM, van der Windt GJW, Tonc E, Schreiber RD, Pearce EJ, Pearce EL (2015).
    Cell 162, 1229-41.
    *equal contribution
  • Cell-intrinsic lysosomal lipolysis is essential for macrophage alternative activation.
    Huang S, Everts B, Ivanova Y, O'Sullivan D, Nascimento M, Smith AM, Beatty W, Love-Gregory L, Lam WY, O'Neill CM, Yan C, Du H, Abumrad NA, Urban JF, Artyomov MN, Pearce EL, Pearce EJ (2014).
    Nat Immunol. 15, 846-855.
  • Memory CD8+ T cells use cell intrinsic lipolysis to support the metabolic programming necessary for development
    . O’Sullivan D, van der Windt GJW, Huang SC, Curtis JD, Chang CC, Buck MD, Qiu J, Smith AM, Lam WY, DiPlato LM, Hsu FF, Birnbaum MJ, Pearce EJ, Pearce EL (2014).
    Immunity 41, 75-88.
  • CD8 memory T cells have a bioenergetic advantage that underlies their rapid recall ability.
    van der Windt GJW, O’Sullivan D, Everts B, Huang SC, Buck MD, Curtis JD, Chang CH, Smith AM, Ai T, Faubert B, Jones RG, Pearce EJ, Pearce EL (2013).
    Proc Natl Acad Sci U S A. 110, 14336-41.
  • Post-transcriptional control of T cell effector function by aerobic glycolysis.
    Chang CH, Curtis JD, Maggi Jr. LB, Faubert B, Villarino AV, O’Sullivan D, Huang SC, van der Windt GJW, Blagih J, Qiu J, Weber JD, Pearce EJ, Jones RG, Pearce EL (2013).
    Cell 153, 1239-51.
  • Mitochondrial respiratory capacity is a critical regulator of CD8(+) T cell memory development.
    Van der Windt GJW, Everts B, Chang CH, Curtis JD, Freitas TC, Amiel E, Pearce EJ, Pearce EL (2012).
    Immunity 36, 68-78.
  • Enhancing CD8 T-cell memory by modulating fatty acid metabolism.
    Pearce EL, Walsh MC, Cejas PJ, Harms GM, Shen H, Wang LS, Jones RG, Choi Y (2009).
    Nature 460, 103-7.