Cluster of Excellence, University of Freiburg

Prof. Dr. Nikolaus Pfanner

Prof. Dr. Nikolaus Pfanner

Institute of Biochemistry and Molecular Biology (Faculty of Medicine)
University of Freiburg

+49 761 203 5223

CIBSS Research Project:

 

10 selected publications:

  • Membrane protein insertion through a mitochondrial β-barrel gate.
    Höhr AIC, Lindau C, Wirth C, Qiu J, Stroud DA, Kutik S, Guiard B, Hunte C, Becker T, Pfanner N*, Wiedemann N* (2018).
    Science 359, eaah6834
  • Mitochondrial OXA translocase plays a major role in biogenesis of inner-membrane proteins.
    Stiller SB, Höpker J, Oeljeklaus S, Schütze C, Schrempp SG, Vent-Schmidt J, Horvath SE, Frazier AE, Gebert N, van der Laan M, Bohnert M, Warscheid B, Pfanner N*, Wiedemann, N* (2016).
    Cell Metab. 23, 901-8.
    *corresponding
  • Central role of Mic10 in the mitochondrial contact site and cristae organizing system.
    Bohnert M, Zerbes RM, Davies KM, Mühleip AW, Rampelt H, Horvath SE, Boenke T, Kram A, Perschil I, Veenhuis M, Kühlbrandt W, van der Klei IJ, Pfanner N*, van der Laan M* (2015).
    Cell Metab. 21, 747-55.
    *corresponding
  • Molecular architecture of the active mitochondrial protein gate.
    Shiota T, Imai K, Qiu J, Hewitt VL, Tan K, Shen HH, Sakiyama N, Fukasawa Y, Hayat S, Kamiya M, Elofsson A, Tomii K, Horton P, Wiedemann N, Pfanner N, Lithgow T, Endo T (2015).
    Science 349, 1544-8.
  • Cell cycle-dependent regulation of mitochondrial preprotein translocase.
    Harbauer AB, Opalińska M, Gerbeth C, Herman JS, Rao S, Schönfisch B, Guiard B, Schmidt O, Pfanner N*, Meisinger C* (2014).
    Science 346, 1109-13.
    *corresponding
  • Mgr2 functions as lateral gatekeeper for preprotein sorting in the mitochondrial inner membrane.
    Ieva R, Schrempp SG, Opaliński L, Wollweber F, Höß P, Heißwolf AK, Gebert M, Zhang Y, Guiard B, Rospert S, Becker T, Chacinska A, Pfanner N*, van der Laan M* (2014).
    Mol Cell 56, 641-52.
    *corresponding
  • Mitochondrial inner membrane protease promotes assembly of presequence translocase by removing a carboxy-terminal targeting sequence.
    Ieva R, Heißwolf AK, Gebert M, Vögtle FN, Wollweber F, Mehnert CS, Oeljeklaus S, Warscheid B, Meisinger C, van der Laan M, Pfanner N (2013).
    Nat Commun. 4, 2853.
  • Regulation of mitochondrial protein import by cytosolic kinases.
    Schmidt O, Harbauer AB, Rao S, Eyrich B, Zahedi RP, Stojanovski D, Schönfisch B, Guiard B, Sickmann A, Pfanner N*, Meisinger C* (2011).
    Cell 144, 227-39.
    *corresponding
  • Global analysis of the mitochondrial N-proteome identifies a processing peptidase critical for protein stability.
    Vögtle FN, Wortelkamp S, Zahedi RP, Becker D, Leidhold C, Gevaert K, Kellermann J, Voos W, Sickmann A*, Pfanner N*, Meisinger C*. (2009).
    Cell 139, 428-39.
    *corresponding
  • Importing mitochondrial proteins: machineries and mechanisms.
    Chacinska A, Koehler CM, Milenkovic D, Lithgow T, Pfanner N (2009).
    Cell 138, 628-44.