Centre for Integrative Biological Signalling Studies
Cluster of Excellence, University of Freiburg

Prof. Dr. Robert Grosse

Prof. Dr. Robert Grosse

Institute of Experimental and Clinical Pharmacology and Toxicology (Faculty of Medicine)
University of Freiburg

+49 761 203 5301

10 selected publications:

  • T cell receptor-triggered nuclear actin network formation drives CD4+ T cell effector functions.
    Tsopoulidis N, Kaw S, Laketa V, Kutscheidt S, Baarlink C, Stolp B, Grosse R Fackler OT (2019).
    Sci Immunol. 4(31). Pii: eaav1987.
  • A transient pool of nuclear F-actin at mitotic exit controls chromatin organization.br /> Baarlink C, Plessner M, Sherrard A, Morita K, Misu S, Virant D, Kleinschnitz EM, Harniman R, Alibhai D, Baumeister S, Miyamoto K, Endesfelder U, Kaidi A, Grosse R (2017).
    Nat Cell Biol. 19(12):1389-1399.
  • MRTF transcription and Ezrin-dependent plasma membrane blebbing are required for entotic invasion.
    Hinojosa LS, Holst M, Baarlink C, Grosse R (2017).
    J Cell Biol. 216(10):3087-3095
  • Junctional actin assembly is mediated by Formin-like 2 downstream of Rac1.
    Grikscheit K, Frank T, Wang Y, Grosse R (2015).
    J Cell Biol. 209(3):367-76.
  • Formin-like 2 Promotes β1-Integrin Trafficking and Invasive Motility Downstream of PKCα.
    Wang Y, Arjonen A, Pouwels J, Ta H, Pausch P, Bange G, Engel U, Pan X, Fackler OT, Ivaska J, Grosse R (2015).
    Dev Cell. 34(4):475-83.
  • G-protein-coupled receptor signaling and polarized actin dynamics drive cell-in-cell invasion.
    Purvanov V, Holst M, Khan J, Baarlink C, Grosse R (2014).
    Elife. doi: 10.7554/eLife.02786.
  • Nuclear actin network assembly by formins regulates the SRF coactivator MAL.
    Baarlink C, Wang H, Grosse R (2013).
    Science. 340(6134):864-7
  • SCAI acts as a suppressor of cancer cell invasion through the transcriptional control of beta1-integrin.
    Brandt DT, Baarlink C, Kitzing TM, Kremmer E, Ivaska J, Nollau P, Grosse R (2009).
    Nat Cell Biol. 11(5):557-68.
  • Positive feedback between Dia1, LARG, and RhoA regulates cell morphology and invasion.
    Kitzing TM, Sahadevan AS, Brandt DT, Knieling H, Hannemann S, Fackler OT, Grosshans J, Grosse R (2007).
    Genes Dev. 21(12):1478-83.
  • Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cells.
    Gaggioli C, Hooper S, Hidalgo-Carcedo C, Grosse R, Marshall JF, Harrington K, Sahai E (2007).
    Nat Cell Biol. 9(12):1392-400.