Cluster of Excellence, University of Freiburg

Prof. Dr. Robert Grosse

Prof. Dr. Robert Grosse

Institute of Experimental and Clinical Pharmacology and Toxicology (Faculty of Medicine)
University of Freiburg

+49 761 203 5301

10 selected publications:

  • T cell receptor-triggered nuclear actin network formation drives CD4+ T cell effector functions.
    Tsopoulidis N, Kaw S, Laketa V, Kutscheidt S, Baarlink C, Stolp B, Grosse R Fackler OT (2019).
    Sci Immunol. 4(31). Pii: eaav1987.
  • A transient pool of nuclear F-actin at mitotic exit controls chromatin /> Baarlink C, Plessner M, Sherrard A, Morita K, Misu S, Virant D, Kleinschnitz EM, Harniman R, Alibhai D, Baumeister S, Miyamoto K, Endesfelder U, Kaidi A, Grosse R (2017).
    Nat Cell Biol. 19(12):1389-1399.
  • MRTF transcription and Ezrin-dependent plasma membrane blebbing are required for entotic invasion.
    Hinojosa LS, Holst M, Baarlink C, Grosse R (2017).
    J Cell Biol. 216(10):3087-3095
  • Junctional actin assembly is mediated by Formin-like 2 downstream of Rac1.
    Grikscheit K, Frank T, Wang Y, Grosse R (2015).
    J Cell Biol. 209(3):367-76.
  • Formin-like 2 Promotes β1-Integrin Trafficking and Invasive Motility Downstream of PKCα.
    Wang Y, Arjonen A, Pouwels J, Ta H, Pausch P, Bange G, Engel U, Pan X, Fackler OT, Ivaska J, Grosse R (2015).
    Dev Cell. 34(4):475-83.
  • G-protein-coupled receptor signaling and polarized actin dynamics drive cell-in-cell invasion.
    Purvanov V, Holst M, Khan J, Baarlink C, Grosse R (2014).
    Elife. doi: 10.7554/eLife.02786.
  • Nuclear actin network assembly by formins regulates the SRF coactivator MAL.
    Baarlink C, Wang H, Grosse R (2013).
    Science. 340(6134):864-7
  • SCAI acts as a suppressor of cancer cell invasion through the transcriptional control of beta1-integrin.
    Brandt DT, Baarlink C, Kitzing TM, Kremmer E, Ivaska J, Nollau P, Grosse R (2009).
    Nat Cell Biol. 11(5):557-68.
  • Positive feedback between Dia1, LARG, and RhoA regulates cell morphology and invasion.
    Kitzing TM, Sahadevan AS, Brandt DT, Knieling H, Hannemann S, Fackler OT, Grosshans J, Grosse R (2007).
    Genes Dev. 21(12):1478-83.
  • Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cells.
    Gaggioli C, Hooper S, Hidalgo-Carcedo C, Grosse R, Marshall JF, Harrington K, Sahai E (2007).
    Nat Cell Biol. 9(12):1392-400.